Yet another weight loss drug fizzles

first_img STAT+ is STAT’s premium subscription service for in-depth biotech, pharma, policy, and life science coverage and analysis. Our award-winning team covers news on Wall Street, policy developments in Washington, early science breakthroughs and clinical trial results, and health care disruption in Silicon Valley and beyond. GET STARTED By Meghana Keshavan Jan. 4, 2017 Reprints What is it? Daily reporting and analysis The most comprehensive industry coverage from a powerhouse team of reporters Subscriber-only newsletters Daily newsletters to brief you on the most important industry news of the day STAT+ Conversations Weekly opportunities to engage with our reporters and leading industry experts in live video conversations Exclusive industry events Premium access to subscriber-only networking events around the country The best reporters in the industry The most trusted and well-connected newsroom in the health care industry And much more Exclusive interviews with industry leaders, profiles, and premium tools, like our CRISPR Trackr. Meghana Keshavan Biotech Correspondent Meghana covers biotech and contributes to The Readout newsletter. When it comes to weight loss, Arena Pharmaceuticals is throwing in the towel.The small San Diego biotech company had once expected its anti-obesity drug, Belviq, to be a blockbuster — after all, more than one-third of Americans are obese. But the market wasn’t interested, and sales never lived up to expectations — leading the company to slash its employee count by 120, nearly three-quarters of its workforce. Biotech Kristoffer Tripplaar/Sipa/AP center_img What’s included? Log In | Learn More About the Author Reprints Yet another weight loss drug fizzles Unlock this article — plus daily coverage and analysis of the biotech sector — by subscribing to STAT+. First 30 days free. GET STARTED [email protected] @megkesh Tags pharmaceuticalsSTAT+last_img read more

ING Diversified Floating Rate Senior Loan Fund closes IPO

Faircourt migrates two closed-end funds to NEO Keywords Closed-end fundsCompanies Connor Clark & Lunn Financial Group Ltd., Clark & Lunn Financial Group Toronto-based Connor, Clark & Lunn Capital Markets Inc. Friday announced the closing of the initial public offering of ING Diversified Floating Rate Senior Loan Fund. The fund raised gross proceeds of $160 million from the sale of 16 million Class A units and US$17,714,670 from the sale of 1,771,467 Class U units. Related news IE Staff Digital Consumer Dividend Fund files IPO The fund has granted to the agents an over-allotment option, exercisable for a period of 30 days from the closing date, to offer an additional 971,024 Class A units. The Class A units are listed on the Toronto Stock Exchange (TSX:IFL.UN). The fund provides exposure to a diversified portfolio consisting primarily of senior, secured floating rate corporate loans and other senior debt obligations of non-investment grade North American borrowers, actively managed by ING Investment Management Co. LLC, the sub-advisor. The portfolio will consist primarily of senior, secured floating rate corporate loans that are expected to generate increased returns in the event that short-term interest rates rise. The fund will not have a fixed distribution policy, but intends to make monthly distributions based on the actual and expected returns on the portfolio. Returns may vary with changes in interest rates. The fund’s initial distribution target is expected to be $0.05 per unit per month (U.S. $0.05 in the case of the Class U units), representing an initial yield on the unit issue price of 6.0% per year. The sub-advisor is an indirect, wholly owned subsidiary of ING Group N.V., one of the world’s largest financial services companies. Connor, Clark & Lunn Capital Markets Inc. will act as manager of the fund. The units are being offered for sale by a syndicate of agents led by BMO Capital Markets and including CIBC, RBC Capital Markets, TD Securities Inc., GMP Securities L.P., National Bank Financial Inc., Scotiabank, Canaccord Genuity Corp., Macquarie Private Wealth Inc., Raymond James Ltd., Desjardins Securities Inc., Mackie Research Capital Corporation and Manulife Securities Inc. Share this article and your comments with peers on social media Europe Blue-Chip Dividend & Growth Fund confirms termination date Facebook LinkedIn Twitter read more

U.S. Imposes New Sanctions on People’s Republic of China Actors Linked to Malign Activities

first_imgU.S. Imposes New Sanctions on People’s Republic of China Actors Linked to Malign Activities The Chinese Communist Party’s malign activity at home and abroad harms U.S. interests and undermines the sovereignty of our allies and partners. The United States will use all countermeasures available, including actions to prevent People’s Republic of China (PRC) companies and institutions from exploiting U.S. goods and technologies for malign purposes. Today’s actions mark yet another sign of our resolve.The United States is imposing new restrictions on certain entities for activities that undermine our national security and foreign policy interests. Specifically, the Department of Commerce is adding 59 PRC entities to its export-control Entity List.Mass Surveillance, Military Modernization, and Human Rights AbusesThe United States is adding four entities to the Entity List for enabling human rights abuses within China by providing DNA-testing materials or high-technology surveillance equipment to the PRC government. We urge the Chinese Communist Party to respect the human rights of the people of China, including Tibetan Buddhists, Christians, Falun Gong members, Uyghur Muslims, and members of other ethnic and religious minority groups.Additionally, the Department of Commerce is adding nineteen entities to the Entity List for systematically coordinating and committing more than a dozen instances of theft of trade secrets from U.S. corporations to advance the PRC defense industrial complex; engaging in activities that undermine U.S. efforts to counter illicit trafficking in nuclear and other radioactive materials; or using U.S. exports to support the PLA and PRC defense industrial base, whose ultimate goal is to surpass the capabilities of other countries they view as competitors, particularly the United States.South China SeaThese new restrictions also impose costs on Beijing’s unlawful campaign of coercion in the South China Sea. The Department of Commerce is adding 25 shipbuilding research institutes affiliated with the China State Shipbuilding Corporation to the Entity List, as well as six other entities that provide research, development, and manufacturing support for the People’s Liberation Army Navy or attempted to acquire U.S.-origin items in support of PLA programs. Commerce is also adding five PRC state-owned enterprises, including the China Communications Construction Company, for their role in coercion of South China Sea claimant states. /Public Release. This material comes from the originating organization and may be of a point-in-time nature, edited for clarity, style and length. View in full here. Why?Well, unlike many news organisations, we have no sponsors, no corporate or ideological interests. We don’t put up a paywall – we believe in free access to information of public interest. Media ownership in Australia is one of the most concentrated in the world (Learn more). Since the trend of consolidation is and has historically been upward, fewer and fewer individuals or organizations control increasing shares of the mass media in our country. According to independent assessment, about 98% of the media sector is held by three conglomerates. This tendency is not only totally unacceptable, but also to a degree frightening). Learn more hereWe endeavour to provide the community with real-time access to true unfiltered news firsthand from primary sources. It is a bumpy road with all sorties of difficulties. We can only achieve this goal together. Our website is open to any citizen journalists and organizations who want to contribute, publish high-quality insights or send media releases to improve public access to impartial information. You and we have the right to know, learn, read, hear what and how we deem appropriate.Your support is greatly appreciated. All donations are kept completely private and confidential.Thank you in advance!Tags:campaign, chinese, communications, Communist Party, Department of State, Government, Human Rights, military, nuclear, Radioactive, religious, research, sanctions, security, South China Sea, surveillance, United Stateslast_img read more

Backing farmers all way

first_imgBacking farmers all way The Hon David Littleproud MPMinister for Agriculture, Drought and Emergency ManagementThe Australian Government has continued its commitment to backing the agricultural industry through the Ag2030 plan.Over $850.0 million has been committed in this year’s budget to drive growth and competitiveness in the agricultural industry.The Australian Government has released the May 2021 Delivering Ag2030 plan, highlighting further measures that the government has put in place to back the agricultural industry as it works towards its goal of $100 billion production by 2030.Minister for Agriculture, Drought and Emergency Management David Littleproud said the agricultural industry has been crucial to the nation’s economic recovery and a shining light in the Australian economy.“Australian farmers, fishers and foresters have put their shoulders to the wheel throughout the pandemic and are expected to deliver a combined $71.2 billion to the Australia economy in 2020-21, up from $66.5 billion in 2019 2020,” Minister Littleproud said.“Today we’ve released our updated May 2021 Delivering Ag2030 plan, which outlines the next stage of government action to support the industry to grow and continue to deliver jobs in regional and rural Australia.“Additional investments in this budget include over $400.0 million to further strengthen biosecurity, $29.8 million to grow the agricultural workforce, and $15.0 million to improve trade and market access.“When the industry announced its Ag2030 goal, we knew it was an ambitious target.“While Australians can expect drought, flood and fire, no one could have expected the widespread impacts of a global pandemic on industry.“Despite these extraordinary circumstances, Australia’s farmers, fishers and foresters responded with determination and resilience.“They got on with the job. They put food on Australian tables, they continued to export to countries all around the world, and they even branched out to look for new markets.“The Australian Government is backing the hard work our agricultural industry puts in by providing over $850.0 million in funding through this year’s budget.“This investment will drive the competitiveness, growth and resilience of the agricultural industry. It will deliver the tools required for producers to reach their goals.“Our farmers and farming communities are playing a leading role in Australia’s economic recovery, creating rural and regional jobs, and we are backing them all the way.” /Public Release. This material comes from the originating organization and may be of a point-in-time nature, edited for clarity, style and length. View in full here. Why?Well, unlike many news organisations, we have no sponsors, no corporate or ideological interests. We don’t put up a paywall – we believe in free access to information of public interest. Media ownership in Australia is one of the most concentrated in the world (Learn more). Since the trend of consolidation is and has historically been upward, fewer and fewer individuals or organizations control increasing shares of the mass media in our country. According to independent assessment, about 98% of the media sector is held by three conglomerates. This tendency is not only totally unacceptable, but also to a degree frightening). Learn more hereWe endeavour to provide the community with real-time access to true unfiltered news firsthand from primary sources. It is a bumpy road with all sorties of difficulties. We can only achieve this goal together. Our website is open to any citizen journalists and organizations who want to contribute, publish high-quality insights or send media releases to improve public access to impartial information. You and we have the right to know, learn, read, hear what and how we deem appropriate.Your support is greatly appreciated. All donations are kept completely private and confidential.Thank you in advance!Tags:Agriculture, Australia, Australian, Australian Government, biosecurity, Emergency, Emergency Management, Government, industry, Investment, Minister, pandemic, production, resilience, rural australia, workforcelast_img read more

PM Hails Syringa Marshall-Burnett as a nation builder

first_imgFacebookTwitterWhatsAppEmail RelatedJamaica Intensifies Ebola Preparedness RelatedRed Stripe to Invest US$10 Million Over Five Years PM Hails Syringa Marshall-Burnett as a nation builderJIS News | Presented by: PausePlay% buffered00:0000:00UnmuteMuteDisable captionsEnable captionsSettingsCaptionsDisabledQualityundefinedSpeedNormalCaptionsGo back to previous menuQualityGo back to previous menuSpeedGo back to previous menu0.5×0.75×Normal1.25×1.5×1.75×2×Exit fullscreenEnter fullscreenPlay Photo: JIS PhotographerLeader of the Opposition, The Most HonourablePortia Simpson Miller, O.N., M.P. RelatedGovernment Allocates $500 Million For National Health Emergency Responsecenter_img Prime  Minister  Portia  Simpson  Miller  has  described  former  President  of  the Senate, Syringa Marshall Burnett, CD, as a nation builder and trail blazer who, as  a  health  care  professional,  educator,  Parliamentarian  and  social  activist, helped  significantly  to  propel  Jamaica’s  development  and  the  advancement  of women.“I am deeply saddened by the passing of one of Jamaica’s finest daughters, who has been a nation builder in her time, and who has contributed so much to the development  of  our  country  and  our  people,”  Prime  Minister  Simpson  Miller said in a statement on Saturday (October 11).The Prime Minister recalled Mrs. Marshall-Burnett‘s national contribution as a pioneering  nurse,  nursing  educator,  Parliamentarian,  tireless  advocate  for senior  citizens  and  one  who  was  passionate  about  the  economic,  social  and professional advancement of women.“As  a  Senator  and  later  President  of  the  Senate,  she  raised  the  bar  of Parliamentary  decorum  by  the  fine  example  she  set.  Her  contributions  were outstanding  and  profound,  and  her  leadership  fair  and  respected,”  Mrs. Simpson Miller added.Mrs. Marshall-Burnett’s past  leadership of the Nurses Association of Jamaica,and her leadership of the National Council for Senior Citizens up to the time of her passing, also received high praise from the Prime Minister. She noted that political association and sympathies were never allowed to diminish the level of professionalism  and  stridency  with  which  Syringa  Marshall-Burnett approached her work as a social activist and advocate.Prime  Minister  Simpson  Miller  said  Mrs.  Marshall-Burnett  freely  gave distinguished service and wise counsel to the People’s National Party serving at the  level  of  the  Executive  Committee,  National  Executive  Council  and  internal commissions.“I  extend  sincere  condolences  to  her  husband  and  other  members  of  her  dear family  at  this  time  of  great  loss  and  sorrow.  We  will  miss  her  outstanding contributions,  incisive  interventions,  her  activism,  her  wise  advice  and  her passion  for  the  development  of  her  country  and  her  fellow  Jamaicans,”  the Prime Minister said. Story HighlightsPrime Minister Portia Simpson Miller has described former President of the Senate, Syringa Marshall Burnett, CD, as a nation builder and trail blazer who, as a health care professional, educator, Parliamentarian and social activist, helped significantly to propel Jamaica’s development and the advancement of women. The Prime Minister recalled Mrs. Marshall-Burnett‘s national contribution as a pioneering nurse, nursing educator, Parliamentarian, tireless advocate for senior citizens and one who was passionate about the economic, social and professional advancement of women.Prime Minister Simpson Miller said Mrs. Marshall-Burnett freely gave distinguished service and wise counsel to the People’s National Party serving at the level of the Executive Committee, National Executive Council and internal commissions. PM Hails Syringa Marshall-Burnett as a nation builder Office of the Prime MinisterOctober 11, 2014Written by: OPM Communications Unit Advertisementslast_img read more

Thai MVNOs form alliance to boost clout

first_img 850MHzCAT TelecomMVNOsThailHaand Joseph Waring AddThis Sharing ButtonsShare to LinkedInLinkedInLinkedInShare to TwitterTwitterTwitterShare to FacebookFacebookFacebookShare to MoreAddThisMore 29 FEB 2016 HomeAsiaNews Thai MVNOs form alliance to boost clout CAT Telecom settles another legal spat CAT Telecom loses compensation claim against AIS Asia Relatedcenter_img Joseph Waring joins Mobile World Live as the Asia editor for its new Asia channel. Before joining the GSMA, Joseph was group editor for Telecom Asia for more than ten years. In addition to writing features, news and blogs, he… Read more Optus gives MVNOs 5G access Previous ArticleIndia’s RCom, Aircel confirm 50:50 wireless ventureNext ArticleMobile Action acquires Appmind Four mobile virtual network operators (MVNOs) that use CAT Telecom’s network have formed an alliance in an attempt to strengthen their bargaining power when negotiating with Thai authorities.The Thailand MVNO Club – which comprises I-Mobile Plus, a subsidiary of Samart, The WhiteSpace, 168 Communication and Myworld 3G — also aims to reduce operating expenses by sharing back-office systems, the Bangkok Post reported.Watchai Vilailuck, chairman of the club and president of Samart, told the Post that an MVNO is a viable business model because it requires relatively low investment for service rollout. “MVNOs will not compete directly with the three major mobile operators. Instead, we are targeting customers in those untapped segments of the market.”Samart has 300,000 subscribers on state-owned TOT’s 2.1GHz network and will launch service on CAT’s 850MHz network next month.Chaiyod Chirabowornkul, chief executive of The WhiteSpace and secretary of the club, noted that while more than 20 companies have MVNO licences from the regulator, only a few can survive, the Post said.In addition to the four companies that will use CAT’s 850MHz network, the state-owned firm plans to partner with three more MVNOs by the end of 2016, including hypermarket Tesco Lotus. Tags Authorlast_img read more

US Cellular CTO charts course to 5G

first_img Diana is Mobile World Live’s US Editor, reporting on infrastructure and spectrum rollouts, regulatory issues, and other carrier news from the US market. Diana came to GSMA from her former role as Editor of Wireless Week and CED Magazine, digital-only… Read more AddThis Sharing ButtonsShare to LinkedInLinkedInLinkedInShare to TwitterTwitterTwitterShare to FacebookFacebookFacebookShare to MoreAddThisMore 13 JUL 2018 Asia Previous ArticleMobile Mix: Episode 6Next ArticleUS DoJ revives AT&T, Time Warner challenge Tags Mike Irizarry, CTO of US Cellular, revealed the nation’s fifth-largest operator is gearing up for a new mmWave 5G trial as it maps out plans to deploy next generation technology.Unlike US Cellular’s previous 5G tests, Irizarry told Mobile World Live the upcoming trial at 28GHz will include standards-based 5G equipment, as well as tests of previously unavailable 5G core technology which will be essential for network slicing.Irizarry declined to name US Cellular’s test partner, but Nokia appears to be the likely contender. The vendor has a pending application with the Federal Communications Commission (FCC) for 28GHz tests with a potential customer in Peoria, Illinois (about three hours from US Cellular’s Chicago headquarters) and a 1 September start date is consistent with a commencement time frame Irizarry mentioned.The CTO said US Cellular views mmWave as hotspot spectrum, ideal for deployments in areas including campuses, event venues and manufacturing locations which demand extreme speed. Broad coverage and moderate speed can be supplied via 5G deployments on low- and mid-band spectrum, he added.But Irizarry said US Cellular is also evaluating mmWave for backhaul.“One of the challenges with deploying small cells is getting fibre to these small cells. If I can use mmWave to cell haul from an adjacent macro cell, I make my deployment of small cells, whether they’re for 4G or 5G, a lot easier.”US Cellular does not own any mmWave assets: its current holdings include 600MHz, 700MHz and 800MHz low-band spectrum; along with mid-band airwaves in the PCS and AWS bands. But Irizarry said the operator is evaluating opportunities which may arise through the FCC’s upcoming mmWave auctions.TimelineTiming is tricky: Irizzary said US Cellular isn’t planning to sit on the sidelines as other operators launch 5G and attempt to poach customers, but noted it makes no sense to deploy a 5G network if there are no devices to take advantage of it. Compatible smartphones aren’t expected to become available until 2019.“We will respond, one if our customers are asking for the technology, and two if we feel there’s a competitive threat in our markets.”While deployment plans are still up in the air, he estimated the operator could launch 5G on its existing low- and mid-band spectrum holdings within a 14- to 18-month time frame.Other work5G planning is just one part of the effort US Cellular is putting into its network.Irizarry said the operator is also testing self-optimising network technology with Ericsson, Nokia and Cisco. The goal, he said, is to use automation and machine learning to help alleviate increasing pressure placed on performance engineers as the network becomes more complex with the introduction of more small cells and C-RAN technology.Additionally, the company is aiming to bolster its LTE network through densification and the introduction of 4G beamforming.He added US Cellular is testing LTE-M technology and is in the process of plotting a deployment plan. Author Telkomsel turns on 5G in major citiescenter_img Related Nokia scores Philippines 5G deal with Dito Home US Cellular CTO charts course to 5G 5GmmWaveUS Cellular Diana Goovaerts Mobile Mix: Buzzing for Barcelonalast_img read more

People urged to stay in primary homes during crisis

first_img Loganair’s new Derry – Liverpool air service takes off from CODA Arranmore progress and potential flagged as population grows Important message for people attending LUH’s INR clinic Nine til Noon Show – Listen back to Monday’s Programme AudioHomepage BannerNews Google+ WhatsApp Twitter Facebook Pinterest By News Highland – March 23, 2020 Google+center_img People urged to stay in primary homes during crisis Pinterest Previous article121 new confirmed cases of Coronavirus cases in IrelandNext articleStobart Air to continue Donegal – Dublin route News Highland Twitter News, Sport and Obituaries on Monday May 24th RELATED ARTICLESMORE FROM AUTHOR WhatsApp Facebook A Donegal TD is urging people to stay in their local area during the Coronavirus pandemic.It follows a number of concerns raised at the weekend over the large number of people travelling to holiday homes, caravan parks and the beaches from outside areas.Deputy Padraig Mac Lochlainn is appealing to people to listen to the advice being given in terms of social distancing and to remain in your primary home.He say seeing people recklessly disregard the advice from public health officials is hugely disappointing:Audio Playerhttps://www.highlandradio.com/wp-content/uploads/2020/03/PadradgdfgdfgdigCaravan.mp300:0000:0000:00Use Up/Down Arrow keys to increase or decrease volume. Community Enhancement Programme open for applicationslast_img read more

Comment / Blog alert on the ease of cyber attacks on ships was pure scaremongering

first_img Last month a much-reported blog – included in The Loadstar – claimed “sinking ships [via hacking], really wouldn’t take much”.Not only was that overly dramatic and not helpful for safety of life at sea, but it was irresponsible as well as being fundamentally flawed: the input assumptions were totally incorrect.The blog jumped around without a logical flow and appeared to conclude that if you corrupted the stowage or Bayplan, via the BAPLIE message – which is given by the terminal to the ship on a USB – that containers could be stowed erroneously to such an extent that it would seriously jeopardise the stability of the vessel.The Bayplan given to the ship is an output from the process. The determination of where specific containers, or categories of containers, are to be loaded is several steps prior to this output.The standard process actually makes data manipulation relatively difficult, as you have two completely different data sets within different organisations and offices, and these need to match at more than 99.5% before loading will be planned or can commence. If you corrupt only one of them, this will trigger a reconciliation process where the error will be detected and corrected with relative ease and in little time.VGM (albeit perhaps not as well enforced as it should be) actually adds an additional layer of security now – although that was not the real purpose of it.In most container terminals, (and the same is likely true at many ship operators’ offices), planning and scheduling software is usually run from networked PCs, which do not have general internet access, partly for security, and partly to keep employees off Facebook or YouTube, This is clearly best practice, and as a policy reduces phishing risks. So it is highly unlikely that one of the two data sets would be deviously manipulated.But this blogger did not stop there: now providing advice to potential criminals as to how they can either pilfer containers or, worse still, get them to explode on ships.He writes of the BAPLIE (Bayplan) message – but makes no mention of the EQD segment, the container number, which would be mandatory. There are many other segments related to intimate consignment details and prices, but you will not find these in any live BAPLIE.EDI messages are somewhat bespoke by design and to implement one, both the sender and receiver need to define the content, while the vast majority of the segments are merely optional. So a successful hack could likely only be made if specific knowledge of an EDI-partnership was known – ie, an inside job and not a random hack.You could amend the discharge port, but the container will not get out from that new port due to other separate security processes, such as BL submission, Customs and ship operator releases. You could also amend the IMDG details in one or other system, but unless they match 100%, the container will not get loaded.It is fine to promote products through the media, but basic facts must be correct, and bloggers must not propagate “fake news”. © Vladimir Balas By Andy Lane, CTI Consultancy 06/12/2017last_img read more

Premium / Supply chain radar: Brookfield’s $4.7bn Oaktree Capital deal – a sign of hard times to come in logistics

first_img Reset Your Password Subscription required for Premium stories In order to view the entire article please login with a valid subscription below or register an account and subscribe to Premium Please Login Premium subscriber LOGIN Email* The first time I privately met the bankers of Oaktree Capital Management in London was soon after Blackstone surrendered control of Klöckner Pentaplast, a German plastic films maker that cost the private equity behemoth a fortune – PE house Cinven won big in those days, getting out of it just before the 2008 meltdown. For Blackstone, the outcome of that investment – in terms of hefty losses – was possibly even worse than CEVA Logistics for Apollo.PipelineHighly focused on corporate restructurings, the … Forgotten your password? Please click here << Go back Email* Reset LOGIN By Alessandro Pasetti 14/03/2019 New Premium subscriber REGISTER Please either REGISTER or login below to continue Password*last_img read more